| 角色 | 饰演者 | 角色介绍 |
| Dr. Alex Cross | 泰勒·派瑞 | |
| Michael Sullivan | 马修·福克斯 | |
| Monica Ashe | 瑞秋·尼科尔斯 | |
| Leon Mercier | 让·雷诺 | |
| Daramus Holiday | 吉安卡洛·埃斯珀西多 | |
| Richard Brookwell | 约翰·C·麦金雷 | |
| Tommy Kane | 爱德华·伯恩斯 | |
| Nana Mama | 西西莉·泰森 | |
| Vincent Dardis | 查德·林伯格 | |
| Maria Cross | 卡门·艾乔戈 | |
| Fan Yau | 斯黛芬妮·查韦斯-乔柯布森 | |
| Paramita Megawati | Jessalyn Wanlim | |
| Janelle Cross | 雅拉·莎希迪 | |
| Bodyguard #3 | Simon Rhee | |
| Officer Sacks | Ingo Rademacher | |
| Erich Nunemacher | Werner D?hn | |
| Damon Cross | Sayeed Shahidi | |
| Tony T. Thompson | Mark Hicks | |
| Jody Klebanoff | 邦妮·本特利 | |
| Soon to be dead man #1 | Christopher Stadulis | |
| Cloche | Marc Tubert | |
| Fight Spectator | Abe Larkin | |
| MMA Fight Fan | 罗恩·考西 | |
| Tyler Perry / Dr. Alex Cross (voice) | Jeff Coopwood | |
| Voice Over Actor | Kaidy Kuna | |
| German Guard | Tiren Jhames | |
| Punk Rock Street kid | Andrew Freij | |
| CPA | Krishawn Peace | |
| Coperation Security Guard #2 | Ron Heisler | |
| Psychiatrist | Sherry Hudak-Weinhardt | |
| Ring Girl | Julie Ariane Russell | |
| Punk Rock | Jairus Devon Hill | |
| Fight Fan | Steven Hauptman | |
| Bomb Squad Commander | Darcy Leutzinger | |
| Man in Black | Brandon Landers | |
| DOG: Zoe Spirit | Shawn Michelle |
