| 角色 | 饰演者 | 角色介绍 |
| Dr. Gail Farmer | 凯思琳·哈罗德 | |
| John Doe #83 / The Sender | 齐杰洛·艾文克 | |
| Jerolyn the Sender's Mother | 雪莉·奈特 | |
| Dr. Joseph Denman Gail's Boss | 保罗·弗里曼 | |
| The Messiah | Sean Hewitt | |
| Dr. Hirsch | Harry Ditson | |
| Dr. Erskine | Olivier Pierre | |
| Young girl | Tracy Harper | |
| Vietnam veteran | Al Matthews | |
| Nurse Jo | Marsha A. Hunt | |
| Sheriff Prouty | Angus MacInnes | |
| Nurse Reimbold | Jana Sheldon | |
| Policeman | Manning Redwood | |
| Policeman | John Stephen Hill | |
| Dr. Warren | Monica Buford | |
| Patient | Janet Brandes | |
| Patient | Peter Carlisle | |
| Patient | Barbara Coles | |
| Patient | Tony Cyrus | |
| Patient | Patrick Field | |
| Patient | Sara Mason | |
| Computer technician | Colin Bruce | |
| Eddie Peter (security guard) | Jerry Harte |
