| Jack Byrnes | 罗伯特·德尼罗
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| Greg Focker | 本·斯蒂勒
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| Kevin Rawley | 欧文·威尔逊
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| Bernie Focker | 达斯汀·霍夫曼
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| Roz Focker | 芭芭拉·史翠珊
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| Dina Byrnes | 布莱思·丹纳
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| Pam Focker | 泰瑞·波罗
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| Andi Garcia | 杰西卡·阿尔芭
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| Prudence | 劳拉·邓恩
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| Nurse Louis | Kevin Hart | |
| Samantha Focker | Daisy Tahan | |
| Henry Focker | Colin Baiocchi | |
| Dr. Bob (as Tom McCarthy) | 托马斯·麦卡锡
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| Randy Weir | 哈威·凯特尔
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| Junior | Yul Vazquez | |
| Chappy | Jack Axelrod | |
| Mr. Androvsky | Clent Bowers | |
| Svetlana | 奥嘉·方达
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| Dr. Patel | Laksh Singh | |
| Stage Producer (as Trula Marcus) | Trula M. Marcus | |
| Rufus | 杰克·凯弗
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| Sleazy Doctor | Rob Huebel
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| EMT | 约翰·迪·玛吉欧
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| EMT | Jordan Peele
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| EMT (as Kello Kirkland Powers) | Kelli Kirkland | |
| Himself | Deepak Chopra | |
| EHS Tough Kid | Robbie Tucker | |
| Young Doctor | 尼克·科罗尔
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| Gustavo | Sergio Calderón
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| Doctor | David Pressman | |
| Doctor | Hugh Dane | |
| Newspaper Vendor | Richard Cotovsky | |
| Kristen | 艾米·斯蒂勒
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| Climbing Kid | Trinity Warren | |
| Climbing Kid | Samuel Schultz | |
| Climbing Kid / Bounce House Kid | Cade Rogers | |
| Climbing Kid | Ava Rose Williams | |
| Climbing Kid (as Frankie M. Torres) | Frankie Torres | |
| Party Kid | Kyla Warren | |
| Party Kid | Erin Haisan | |
| Party Kid | Ryder Bucaro | |
