| Superman / Clark Kent (as Superman) | 柯克·阿林
 | |
| Lois Lane | Noel Neill
 | |
| Jimmy Olsen | Tommy Bond | |
| 'Spider Lady' | Carol Forman | |
| Henchman Driller | George Meeker | |
| Henchman Anton | Jack Ingram | |
| Perry White | Pierre Watkin | |
| Henchman Brock | Terry Frost | |
| Henchman Conrad [Chs. 6-15] | Charles King | |
| Dr. Hackett [Chs. 6-15] | Charles Quigley | |
| Dr. Arnold Graham [Chs. 3 9-11 13-15] | Herbert Rawlinson | |
| Prof. Arnold Leeds [Chs. 3-4] | Forrest Taylor | |
| Morgan [Chs. 3-4] | Stephen Carr | |
| Henchman Elton [Chs. 7-15] | Rusty Wescoatt | |
| Policeman at Museum [Ch. 5] (uncredited) | Fred Aldrich | |
| Taxi Driver [Ch. 2] (uncredited) | Phil Arnold | |
| Wave Tracer [Ch.10] (uncredited) | Jimmy Aubrey | |
| Ro-Zon leader of Krypton [Ch. 1] (uncredited) | Robert Barron | |
| Martha Kent [Ch. 1] (uncredited) | Virginia Carroll | |
| Eben Kent [Ch. 1] (uncredited) | Ed Cassidy | |
| Dupe [Ch. 14] (uncredited) | Jack Chefe | |
| Auto Mechanic [Ch. 10] (uncredited) | 埃德蒙·科博
 | |
| Agent with Crandall [Ch. 3] (uncredited) | George DeNormand | |
| Clark as a small boy [Ch. 1] (uncredited) | Alan Dinehart III | |
