| 角色 | 饰演者 | 角色介绍 |
| Sherlock Holmes | 小罗伯特·唐尼 | |
| Dr. John Watson | 裘德·洛 | |
| Madam Simza Heron | 劳米·拉佩斯 | |
| Irene Adler | 瑞秋·麦克亚当斯 | |
| Professor James Moriarty | 杰瑞德·哈里斯 | |
| Mycroft Holmes | 斯蒂芬·弗雷 | |
| Colonel Sebastian Moran | 保罗·安德森 | |
| Mary Watson | 凯利·蕾莉 | |
| Mrs. Hudson | 杰拉丁尼·詹姆斯 | |
| Inspector Lestrade | 埃迪·马森 | |
| Constable Clark | William Houston | |
| Doctor Hoffmanstahl | Wolf Kahler | |
| Auctioneer | Iain Mitchell | |
| Carruthers | Jack Laskey | |
| Shush Club Maitre D' | Patricia Slater | |
| Shush Club Maitre D' | 卡丽玛·阿德贝 | |
| Businessman | Richard Cunningham | |
| Hashisheen | Marcus Shakesheff | |
| Cock Fight Referee | Mark Sheals | |
| University Student | George Taylor | |
| Vicar | Michael Webber | |
| Train Conductor | Mike Grady | |
| Twin | 亚利山德烈·卡里尔 | |
| Twin | 维克多·卡里尔 | |
| Alfred Meinhard | Thorston Manderlay | |
| Tamas | Affif Ben Badra | |
| Marko | Daniel Naprous | |
| Stefan | Lancelot Weaver | |
| Andrzej (as Vladimir Furdik) | Vladimir 'Furdo' Furdik | |
| Gypsy Kid | Jacques Senet Larson | |
| Gypsy Kid | Nicolas Senet Larson | |
| Gypsy Kid | Sebastian Senet Larson | |
| Gypsy | Alexander Devrient | |
| Gypsy | Fatima Adoum | |
| Stanley | Stanley Kaye | |
| Claude Ravache | 蒂埃里·钮维 | |
| Commendatore | Martin Nelson |
