| Detective Vic Mackey (2002-) | 迈克尔·切克利斯
 | |
| Captain Monica Rawling (2005) | 格伦·克洛斯
 | |
| Officer Danielle "Danny" Sofer (2002-) | Catherine Dent
 | |
| Detective Shane Vendrell (2002-) | 沃特·戈金斯
 | |
| Officer Julien Lowe (2002-) | Michael Jace | |
| Detective Curtis "Lemonhead" Lemansky (2002-) (as Kenneth Johnson) | 肯尼·强森
 | |
| Detective Holland "Dutch" Wagenbach (2002-) | 杰·卡尔内斯
 | |
| Captain David Aceveda (2002-) | Benito Martinez | |
| Detective Claudette Wyms (2002-) | 希·庞德
 | |
| Corrine Mackey (2002-) | Cathy Cahlin Ryan | |
| Detective Ronnie Gardocki (2002-) | David Rees Snell | |
| Lt. Jon Kavanaugh (2006-) | 福里斯特·惠特克
 | |
| Detective Steve Billings? (42 episodes 2005-2008) | David Marciano | |
| Cassidy Mackey (35 episodes 2002-2008) | Autumn Chiklis | |
| Officer Tina Hanlon (32 episodes 2006-2008) | 鲍拉·加茜丝
 | |
| Mara Sewell Vendrell? (25 episodes 2004-2008) | Michele Hicks | |
| Paula (22 episodes 2002-2008) | Melanie Myers | |
| Matthew Mackey (19 episodes 2002-2004) | Joel Rosenthal | |
| Ray Carlson (17 episodes 2002-2008) | Matt Corboy
 | |
| Officer Asher (16 episodes 2005-2008) | Chaney Kley | |
