| Jack Sparrow | 约翰尼·德普
 | |
| Angelica | 佩内洛普·克鲁兹
 | |
| Barbossa | 杰弗里·拉什
 | |
| Blackbeard | 伊恩·麦柯肖恩
 | |
| Gibbs | 凯文·麦克纳利
 | |
| Philip | 山姆·克拉弗林
 | |
| Syrena | 阿斯特丽德·伯格斯-弗瑞斯贝
 | |
| Scrum | 斯蒂芬·格拉汉姆
 | |
| Captain Teague | 基思·理查兹
 | |
| King George | 理查德·格雷弗斯
 | |
| Groves | 格雷格·艾里斯
 | |
| Gillette | 戴米恩·欧·海尔
 | |
| The Spaniard | 奥斯卡·贾恩那达
 | |
| Lord John Carteret | Anton Lesser | |
| Prime Minister Henry Pelham | 罗杰·阿拉姆
 | |
| Society Lady | 朱迪·丹奇
 | |
| Ezekiel | 克里斯托弗·费尔班克
 | |
| Salaman | Paul Bazely | |
| Cook | 布隆森·韦伯
 | |
| Derrick | Richard Thomson | |
| Garheng | 松崎悠希
 | |
| Cabin Boy | 罗比·凯
 | |
| Purser | 斯蒂夫·艾弗茨
 | |
| Quartermaster | Ian Mercer | |
| Gunner | 道比·欧帕瑞
 | |
| Tamara ? First Mermaid | 嘉玛·沃德
 | |
| King Ferdinand | Sebastián Fernández-Armesto | |
| Spanish Sea Captain | Carlos Vellido | |
| Spanish Fisherman | Tristan Laurence Perez | |
| Spanish Castaway | Norberto Morán | |
| Spanish Officer | Gerard Monaco | |
| Spanish Soldier | Tyrone Lopez | |
| Captain of the Guard | 卢克·罗伯茨
 | |
| Guard | Daniel Ings | |
| English Girl | Emilia Jones | |
| English Father | 帕特里克·肯尼迪
 | |
| Jailor | 乔迪·哈尔斯 | |
| Bailiff | Clifford Rose | |
| Foreman | Paul Hunter | |
| Mermaid | Jorgelina Guadalupe Airaldi | |
| Mermaid | Brea Berrett | |
| Mermaid | Sanya Hughes | |
| Mermaid | Daphne Joy | |
| Mermaid | Antoinette Nikprelaj | |
