| Malcolm / Big Momma | 马丁·劳伦斯
 | |
| Sherri | 尼娅·朗
 | |
| Leah Fuller | 艾米丽·普格特
 | |
| Kevin | 扎克瑞·莱维
 | |
| Tom Fuller | 马克·摩斯
 | |
| Molly | 凯特·戴琳斯
 | |
| Carrie (as Chloe Grace Moretz) | 科洛·莫瑞兹
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| Liliana Morales | 马利索·妮可
 | |
| Stewart | 乔什·佛雷特
 | |
| Crawford | Dan Lauria | |
| Trent | Jascha Washington | |
| Andrew | Preston Shores | |
| Andrew | Trevor Shores | |
| Constance (as Sarah Joy Brown) | 莎拉·布朗
 | |
| Mrs. Gallagher | 罗达·格里菲斯
 | |
| Oshima | 凯文·杜兰
 | |
| Casal | 卡梅隆·达多
 | |
| Bishop (as Christopher Michael Jones) | Christopher Jones | |
| Yasmeen | Jeanene Fox | |
| Doug Hudson | Kirk B.R. Woller
 | |
| Principal | Andy Stahl | |
| Brian | Mark Joy | |
| Ryan | Christopher Tavarez | |
| Trent's Friend | Bryan James Kitto | |
| FBI Agent #1 | Ramsey Luke | |
| FBI Agent #2 | Lonnie Lamont | |
| Erskine | 马库斯·里尔·布朗
 | |
| Petra | 珊娜·莫克勒
 | |
| Isabella | Yvonne Landry | |
| Danielle | Lisa Arrindell Anderson | |
| Fuller's Secretary Lucy | 米赫拉·布鲁姆
 | |
| Coach Bonnie | Wendy Braun
 | |
| Coach Lisa | Ann Mahoney
 | |
| Tassie | Deneen Tyler | |
| Chad | Max Van Ville
 | |
| Cabbie | Sean Lampkin | |
| Bob | 威廉·罗格斯戴尔
 | |
| Surf Shop Girl | Kelly Dowdle | |
| Mall Artist | Arthur Simone | |
| Mall Old Man | Stocker Fontelieu | |
| Bra Model | 杰西卡·怀特
 | |
| Spa Susan | Amy Morris | |
| Spa Joanne | Michelle Parylak | |
