| 角色 | 饰演者 | 角色介绍 |
| The Creature | 罗伯特·德尼罗 | |
| Victor Frankenstein | 肯尼思·布拉纳 | |
| Henry Clerval | 汤姆·休斯克 | |
| Elizabeth | 海伦娜·伯翰·卡特 | |
| Captain Robert Walton | 艾丹·奎因 | |
| Baron Frankenstein | 伊安·霍姆 | |
| Grandfather | 理查德·布赖尔斯 | |
| Professor Waldman | 约翰·克立斯 | |
| Professor Krempe | Robert Hardy | |
| Victor's Mother | 切瑞·朗西 | |
| Mrs. Moritz | 西莉亚·伊姆瑞 | |
| Justine | Trevyn McDowell | |
| Claude | Gerard Horan | |
| Felix | Mark Hadfield | |
| Marie | Joanna Roth | |
| Maggie | Sasha Hanau | |
| Thomas | Joseph England | |
| Landlord | Alfred Bell | |
| Minister | Richard Clifford | |
| Policeman | George Asprey | |
| Schiller | 休·博内威利 | |
| William | Ryan Smith | |
| Young William | Charles Wyn-Davies | |
| Young Victor | 罗里·詹宁斯 | |
| Young Justine | Christina Cuttall | |
| Young Elizabeth | 汉娜·泰勒-高登 | |
| Frau Brach | Susan Field | |
| Grigori | Jimmy Yuill | |
| Ship's Crew #1 | Chris Barnes | |
| Ship's Crew #2 | Shaun Prendergast | |
| Ship's Crew #3 | Tommy Wright | |
| Ship's Crew #4 | David Kennedy | |
| Ship's Crew #5 | Paul Gregory | |
| Ship's Crew #6 | Chris Hollis | |
| Ship's Crew #7 | Robin Lloyd | |
| Ship's Crew #8 | Alex Lowe | |
| Ship's Crew #9 | Graham Loughridge | |
| Ship's Crew #10 | Simon Cox | |
| Ship's Crew #11 | Robert Hines | |
| Rough Woman | Lonnie James |
