| 角色 | 饰演者 | 角色介绍 |
| Sherlock Holmes | 爱德华·伍德华德 | |
| Dr. John Watson | John Hillerman | |
| Prof. Moriarty | 安东尼·安德鲁斯 | |
| Sophy DeVere | 金·索姆森 | |
| Mycroft Holmes | Peter Jeffrey | |
| Col. Gould | 沃伦·克拉克 | |
| Insp. Lestrade | Terence Lodge | |
| Stubb | 克里斯托弗·费尔班克 | |
| Richard Farrington | Harry Audley | |
| Finch | David Sibley | |
| Berton | John Tordoff | |
| Kasim | Michael Tezcan | |
| Wiggins | Daniel Newman | |
| Mrs. Hudson | Faith Kent | |
| Minister | David Neal | |
| Policeman | Steve Ellis | |
| Police driver | David Arlen | |
| Ballad singer | Graham Gill | |
| Wickes | Jimmy Flint | |
| Old drunk | Ronald Nunnery | |
| Preacher | Geoffrey Rose | |
| Hangman | Peter Brace | |
| Queen Victoria | Honora Burke | |
| Baker Street Irregular | Ben Waters | |
| Baker Street Irregular | Mathew Baker | |
| Baker Street Irregular | Ben Davis | |
| Baker Street Irregular | Tony Vaughn | |
| Baker Street Irregular | David King |
