| 角色 | 饰演者 | 角色介绍 |
| Kate / Offred | 娜塔莎·理查德森 | |
| Serena Joy | 费·唐纳薇 | |
| Nick | 艾丹·奎因 | |
| Moira | 伊丽莎白·麦戈文 | |
| Commander | 罗伯特·杜瓦尔 | |
| Guardian | 缪斯·沃森 | |
| Doctor (uncredited) | 大卫·杜克斯 | |
| Aunt Lydia | Victoria Tennant | |
| Ofglen | Blanche Baker | |
| Janine / Ofwarren | Traci Lind | |
| Aunt Helena | Zoey Wilson | |
| Aunt Elizabeth | Kathryn Doby | |
| Luke (as Rainer Schoene) | Reiner Sch?ne | |
| Cora | Lucia Hartpeng | |
| Aunt Sara | Karma Ibsen Riley | |
| Rita | Lucile McIntyre | |
| Officer on Bus | Gary Bullock | |
| June | Allison Holmes | |
| Preacher | J. Michael Hunter | |
| Dick (as Robert Raiford) | Robert D. Raiford | |
| Alma | Mirjam Bohnet | |
| TV Announcer #1 (as Julian E. Bell) | Julian Bell | |
| Guard | David Barnes | |
| Angel at Desk | James A. Carleo III | |
| Eye in Van | Jim Grimshaw | |
| Eye | Ival Migel | |
| Aunt | Doris Boggs | |
| Aunt Christina | Annemarie Fenske | |
| Wife #2 | Linda Pierce | |
| Wife #3 | Nina Lynn Blanton | |
| Mrs. Warren | Rhesa Reagan Stone | |
| Handmaid | Sara Seidman | |
| Martha | Janell McLeod | |
| Hostess | Elke Ritschel | |
| Nun | Jane Learned | |
| Condemned Man (as Randell Haynes) | Randell Haynes | |
| Black Woman | Rhonda Bond | |
| Wardress | Mil Nicholson | |
| Guard #1 | Robert Pentz | |
| Guard #2 | Tom McGovern |
