| 角色 | 饰演者 | 角色介绍 |
| Meg Murry | Katie Stuart | |
| Calvin O'Keefe | 格里高利·史密斯 | |
| Charles Wallace Murry | 大卫·多夫曼 | |
| Dr. Jack Murry | 克里斯·波特 | |
| The Man With Red Eyes | Kyle Secor | |
| Happy Medium | Sean Cullen | |
| Dr. Dana Murry | Sarah-Jane Redmond | |
| Mrs. Which | 凯特·尼利甘 | |
| Mrs. Who | 艾丽森·艾略特 | |
| Mrs. Whatsit | 阿尔法·沃德 | |
| Sandy Murry | Munro Chambers | |
| Dennys Murry | Thomas Chambers | |
| Aunt Beast | Ellen Dubin | |
| Bingo Man | Guy Fauchon | |
| Eric O'Keefe | 亚历山大·波洛克 | |
| Max | Bryce Hodgson | |
| Louie | Matthew Brevner | |
| Isabel | Rachel Victoria | |
| Mr. Porter | Norman Armour | |
| Mr. Jenkins | Roger Haskett | |
| Ms. Myles | Angela Moore | |
| Young Meg | Angelica Kero | |
| Calvin's Mom (as Nancy Lilley) | Nancy J. Lilley | |
| Billy | Jeff Ballard | |
| Billy's Mom | Anita Adams | |
| Valentina Tereshkova | Apollonia Vanova | |
| 14 Year Old "IT" Girl | Alexa Fox | |
| 16 Year Old "IT" Boy | Noel Fisher | |
| 6 Year Old "IT" Girl | Jacoba Rozema | |
| School Girl # 1 | Christine Kennedy | |
| School Girl # 2 (as Sarah La Greca) | Sarah Le Greca | |
| Camazotz Boy # 1 | Robbie Ruddell | |
| Stone Face | Peter Benson | |
| Camazotz Lady | Iris Quinn | |
| Guard # 1 | Shawn Reis | |
| Secretary | Sarah Hayward | |
| Ubalon (uncredited) | 保罗·贝克尔 |
