| Dib? (27 episodes 2001-2006) | Andy Berman | |
| ZIM? (26 episodes 2001-2006) | Richard Steven Horvitz | |
| GIR? (25 episodes 2001-2006) | Rosearik Rikki Simons | |
| Gaz? (21 episodes 2001-2006) | Melissa Charles | |
| Computer? (19 episodes 2001-2006) | Jhonen Vasquez | |
| Professor Membrane? (18 episodes 2001-2006) | Rodger Bumpass | |
| Ms. Bitters? (13 episodes 2001-2006) | Lucille Bliss | |
| Almighty Tallest Red? (13 episodes 2001-2006) | Wally Wingert | |
| Zita? (13 episodes 2001-2006) | 莫·柯林斯
 | |
| Almighty Tallest Purple? (10 episodes 2001-2006) | 凯文·麦克唐纳
 | |
| Neighbor? (9 episodes 2001-2006) | 弗莱德·塔他斯西奥
 | |
| Poonchy? (6 episodes 2001-2006) | Paul Greenberg | |
| Assistant #1? (6 episodes 2001-2006) | David Herman | |
| Gretchen? (6 episodes 2001-2002) | Antoinette Spolar | |
| Mysterious Mysteries Anchor? (5 episodes 2001-2006) | John Garry | |
| Announcer? (5 episodes 2001-2002) | Brad Abrell | |
| Melvin? (5 episodes 2001-2006) | Danny Cooksey | |
| Abductor Blue? (5 episodes 2001-2006) | Eric Trueheart | |
| M? (5 episodes 2001-2002) | 菲尔·拉马
 | |
| Presidentman? (4 episodes 2001-2006) | 杰弗瑞·琼斯 | |
