| Lightning McQueen (voice) | 欧文·威尔逊
 | |
| Mater (voice) | 王牌接线员拉里
 | |
| Finn McMissile (voice) | 迈克尔·凯恩
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| Holley Shiftwell (voice) | 艾米莉·莫迪默
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| Sir Miles Axlerod (voice) | 艾迪·伊扎德
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| Francesco Bernoulli (voice) | 约翰·特托罗
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| Brent Mustangburger (voice) | Brent Musburger | |
| Grem (voice) | 乔·曼特纳
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| Professor Z (voice) | 托马斯·克莱舒曼
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| Acer (voice) | 彼得·雅各布森
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| Sally (voice) | 邦尼·亨特
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| Darrell Cartrip (voice) | Darrell Waltrip | |
| Uncle Topolino (voice) | 弗兰科·尼罗
 | |
| David Hobbscap (voice) | David Hobbs | |
| Mel Dorado (voice) | Patrick Walker | |
| Luigi (voice) | 托尼·夏尔赫布
 | |
| Otis (voice) | 杰夫·格尔林
 | |
| Tomber (voice) | Michel Michelis | |
| Siddeley & Leland Turbo (voice) | 詹森·艾萨克
 | |
| Fillmore & Combat Ship (voice) | Lloyd Sherr | |
| Rod 'Torque' Redline (voice) | 布鲁斯·坎贝尔
 | |
| Mater's Computer (voice) | Teresa Gallagher | |
| Flo (voice) | 詹妮弗·路易斯
 | |
| Victor Hugo / Vladimir Trunkov / Ivan the Tow Truck (voice) | Stanley Townsend | |
| Alexander Hugo (voice) | Velibor Topic | |
| Crabby (voice) | Sig Hansen | |
| Guido (voice) | Guido Quaroni | |
| The Queen / Mama Topolino (voice) | 瓦妮莎·雷德格瑞夫
 | |
| J. Curby Gremlin (voice) | John Mainieri | |
| Tubbs Pacer (voice) | 布拉德·刘易斯 | |
