| 角色 | 饰演者 | 角色介绍 |
| Alice | 米拉·乔沃维奇 | |
| Claire Redfield | 艾丽·拉特 | |
| Chris Redfield | 文特沃斯·米勒 | |
| Bennett | 金·寇兹 | |
| Albert Wesker | 肖恩·罗伯茨 | |
| Angel Ortiz | 塞尔乔·佩里斯-曼切塔 | |
| K-Mart | 史宾塞·洛克 | |
| Luther West | 波瑞斯·科乔 | |
| Jill Valentine | 西耶娜·盖尔利 | |
| Crystal | 凯茜·巴恩费尔德 | |
| Kim Yong | 杨立文 | |
| Wendell | Fulvio Cecere | |
| Axeman | 雷·奥鲁鲍威尔 | |
| Sniper #1 | Christopher Kano | |
| Sniper #2 | Tatsuya Goke | |
| Technician #1 | Nobuya Shimamoto | |
| Duty Officer | Peter Kosaka | |
| Captain Hotaka | Dennis Akayama | |
| Technician #2 | Kenta Tomeoki | |
| Umbrella Sergeant | Shin Kawai | |
| J Pop Girl | 中岛美嘉 | |
| Business Man | Takato Yamashita | |
| Kogel Girl Undead | Hiromi Okuyama | |
| Featured Zombie (uncredited) | Bill Blair | |
| Zombie (uncredited) | Evin Michaels | |
| Zombie (uncredited) | Devon Richards |
