| Meatwad? (99 episodes 2000-2010) | Dave Willis | |
| Master Shake (98 episodes 2000-2010) | Dana Snyder | |
| Frylock (91 episodes 2000-2010) | Carey Means | |
| Dr. Weird? (42 episodes 2000-2009) | C. Martin Croker | |
| Err? (40 episodes 2001-2010) | Matt Maiellaro | |
| Narrator (23 episodes 2000-2006) | Schooly-D | |
| Oglethorpe? (21 episodes 2001-2006) | Andy Merrill | |
| Emory? (18 episodes 2002-2005) | Mike Schatz | |
| Announcer? (7 episodes 2003-2008) | Edward Hastings | |
| Cop? (6 episodes 2002-2009) | George Lowe | |
| MC Pee Pants? (6 episodes 2002-2004) | Chris Ward | |
| Tree? (6 episodes 2003-2005) | Nick Ingkatanuwat | |
| Mothmonsterman? (5 episodes 2001-2009) | H. Jon Benjamin
 | |
| Assistant? (4 episodes 2003-2009) | Jay Edwards | |
| Cliff? (4 episodes 2002-2008) | Vishal Roney | |
| Satan? (4 episodes 2003-2006) | Jim Fortier | |
| Grocery Shopper? (3 episodes 2009-2010) | Dana Swanson | |
| Happy Time Harry? (3 episodes 2002-2008) | 大卫·克罗斯
 | |
| DP? (3 episodes 2003-2006) | 帕顿·奥斯瓦尔特
 | |
| Computer? (3 episodes 2001-2002) | Mary Kraft | |
| Flargan? (3 episodes 2001-2003) | Scott Hilley | |
| Oog? (3 episodes 2003) | Jon Glaser | |
